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Ro 0281675 结构式

Ro 0281675

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP16457CAS号 :300353-13-3纯度:98%
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  • 基本信息与产品描述
CAS号 300353-13-3 货号 BCP16457
中文名 Ro 0281675
英文名 Ro 0281675
中文别名
英文别名 Ro-0281675;Ro0281675; Ro 28-1675;
SMILES
化学名称
分子式 C18H22N2O3S2 分子量 378.51
纯度 98% 配送 惯例下常温包邮
产品描述 IC50 value: 0.24± 0.0019 uM (SC1.5) Target: Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with a SC1.5 of 0.24 uM, while the S isomer did not activated GK up to 10 uM. Oral administration of Ro 28-1675 (50 mg/Kg) to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle treated animals . Comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Following a single oral dose, Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT, was well tolerated, and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg).
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