Ro 0281675

  • 化学数据
CAS号 300353-13-3 货号 BCP16457
中文名 Ro 0281675
英文名 Ro 0281675
中文别名
英文别名 Ro-0281675;Ro0281675; Ro 28-1675;
分子式 C18H22N2O3S2 分子量 378.51
  • 用途
生物活性 IC50 value: 0.24± 0.0019 uM (SC1.5) Target: Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with a SC1.5 of 0.24 uM, while the S isomer did not activated GK up to 10 uM. Oral administration of Ro 28-1675 (50 mg/Kg) to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle treated animals . Comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Following a single oral dose, Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT, was well tolerated, and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg).
信号通路 Protease/Metabolic Enzyme 
靶 点 Glucokinase 

结构式

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