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CAS号 | 1361224-53-4 | 货号 | BCP19926 |
中文名 | AMG-3969 | ||
英文名 | AMG-3969 | ||
中文别名 | |||
英文别名 | AMG3969;AMG 3969; | ||
SMILES | CC#C[C@@H]1N(C2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)CCN(S(=O)(C3=CN=C(N)C=C3)=O)C1 | ||
化学名称 | |||
分子式 | C21H20F6N4O3S | 分子量 | 522.46 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AMG-3969 is a GK-GKRP disruptor. AMG-3969 normalized blood glucose levels in several rodent models of diabetes. AMG-3969 potently reversed the inhibitory effect of GKRP on GK activity and promoted GK translocation both in vitro (isolated hepatocytes) and in vivo (liver). AMG-3969 blood glucose lowering was restricted to diabetic and not normoglycaemic animals. |
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