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CAS号 | 1442684-77-6 | 货号 | BCP18588 |
中文名 | AM2394 | ||
英文名 | AM2394 | ||
中文别名 | |||
英文别名 | AM-2394;AM 2394; | ||
SMILES | O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CC=C(OCC(C)(O)C)N=C3)C=N1 | ||
化学名称 | |||
分子式 | C22H25N5O4 | 分子量 | 423.47 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. |
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