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  >   ONC-201 Dihydrochloride
ONC-201 Dihydrochloride 结构式

ONC-201 Dihydrochloride

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP46830CAS号 :1638178-82-1纯度:98%
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  • 基本信息与产品描述
CAS号 1638178-82-1 货号 BCP46830
关联产品 1616632-77-9(ONC201) 41276-02-2(TIC10 Analogue)
中文名 ONC-201 Dihydrochloride
英文名 ONC-201 Dihydrochloride
中文别名
英文别名 ONC201 2HCl;ONC 201 2HCl;ONC-201 2HCl;
SMILES CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5.Cl.Cl
化学名称
分子式 C24H28Cl2N4O 分子量 459.42
纯度 98% 配送 惯例下常温包邮
产品描述 ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.
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