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ONC201 结构式

ONC201

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP14991CAS号 :1616632-77-9纯度:98%
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  • 基本信息与产品描述
CAS号 1616632-77-9 货号 BCP14991
关联产品 41276-02-2(TIC10 Analogue) 1638178-82-1(ONC-201 Dihydrochloride)
中文名 ONC201
英文名 ONC201
中文别名
英文别名 ONC-201;ONC 201;TIC-10;TIC 10;TIC10;Dordaviprone;
SMILES CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5
化学名称
分子式 C24H26N4O 分子量 386.49
纯度 98% 配送 惯例下常温包邮
产品描述 Akt/ERK Inhibitor ONC201 is a water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, Akt/ERK inhibitor ONC201 binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier.
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