ONC-201 Dihydrochloride

  • 化学数据
CAS号 1638178-82-1 货号 BCP46830
中文名 ONC-201 Dihydrochloride
英文名 ONC-201 Dihydrochloride
中文别名
英文别名 ONC201 2HCl;ONC 201 2HCl;ONC-201 2HCl;
分子式 C24H28Cl2N4O 分子量 459.42
  • 用途
生物活性 ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.
上下游产品 1616632-77-9(ONC201) 41276-02-2(TIC10 Analogue)
信号通路 Apoptosis Pathway PI3K/Akt/mTOR MAPK Pathway 
靶 点 TNF Receptor MEK/ERK AKT 

结构式

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