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| CAS号 | 2055597-12-9 | 货号 | BCP48479 |
| 关联产品 | 2055597-39-0（ASN007 benzenesulfonate） | ||
| 中文名 | ASN007 | ||
| 英文名 | ASN007 | ||
| 中文别名 | |||
| 英文别名 | ASN-007; ASN 007;Erk-IN-3; | ||
| SMILES | CC1=CN=C(N=C1N2C=C(N=C2)C(=O)NC(CN)C3=CC(=CC(=C3)Cl)F)NC4CCOCC4 | ||
| 化学名称 | |||
| 分子式 | C22H25ClFN7O2 | 分子量 | 473.93 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines. | ||
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Tags:ASN007 供应商,ASN007 购买,ASN007 生产,ASN007 批量,ASN007 供应,ASN007 订购,ASN007 采购