AM2394
CAS号 | 1442684-77-6 | 货号 | BCP18588 |
中文名 | AM2394 | ||
英文名 | AM2394 | ||
中文别名 | |||
英文别名 | AM-2394;AM 2394; | ||
分子式 | C22H25N5O4 | 分子量 | 423.47 |
生物活性 | AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. | ||
信号通路 | Protease/Metabolic Enzyme | ||
靶 点 | Glucokinase |
结构式
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