ODM-203 新
参考资料
仅供科学研究,不可用于个人用途。
规格 | 价格(CNY) | 是否现货 | 购买咨询 |
---|---|---|---|
5.00 mg | ¥540.00 | In-stock | 购买咨询 |
10.00 mg | ¥910.00 | In-stock | 购买咨询 |
50.00 mg | ¥2650.00 | In-stock | 购买咨询 |
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CAS号 | 1430723-35-5 | 货号 | BCP30030 |
中文名 | ODM-203 | ||
英文名 | ODM-203 | ||
中文别名 | |||
英文别名 | ODM203;ODM 203; | ||
SMILES | |||
化学名称 | |||
分子式 | C26H21F2N5O2S | 分子量 | 505.54 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM); suppresses 9/317 additional kinases by >70% at 1 uM, 9 kinases suppressed by ODM-203 - DDR1, MAP4K4, MINK1, RET, PDGFRa and SIK2 (IC50<100 nM); ODM-203 is a potent inhibitor of FGFR signaling and proliferation in several FGFR-dependent cell lines; ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nM) with similar potency as it inhibits proliferation in FGFR-dependent cell lines (IC50 50-150 nM); inhibits FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts. |
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