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CAS号 | 2070931-57-4 | 货号 | BCP46002 |
关联产品 | 2388506-44-1(MAX-40279半己二酸 ) 2388506-43-0(MAX-40279半富马酸盐) | ||
中文名 | MAX-40279 | ||
英文名 | MAX-40279 | ||
中文别名 | |||
英文别名 | MAX 40279; MAX40279; | ||
SMILES | CC1=C(C2=NC(=NC=C2S1)NC3=CN(N=C3)C4CCNCC4)C5=C(C=C(C=C5)F)OC | ||
化学名称 | |||
分子式 | C22H23FN6OS | 分子量 | 438.52 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | FLT3/FGFR Dual Kinase Inhibitor MAX-40279 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival. |
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