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MAX-40279 结构式

MAX-40279

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货号 :BCP46002CAS号 :2070931-57-4纯度:98%
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  • 基本信息与产品描述
CAS号 2070931-57-4 货号 BCP46002
关联产品 2388506-44-1(MAX-40279半己二酸 ) 2388506-43-0(MAX-40279半富马酸盐)
中文名 MAX-40279
英文名 MAX-40279
中文别名
英文别名 MAX 40279; MAX40279;
SMILES CC1=C(C2=NC(=NC=C2S1)NC3=CN(N=C3)C4CCNCC4)C5=C(C=C(C=C5)F)OC
化学名称
分子式 C22H23FN6OS 分子量 438.52
纯度 98% 配送 惯例下常温包邮
产品描述 FLT3/FGFR Dual Kinase Inhibitor MAX-40279 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival.
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