即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 2408648-20-2 | 货号 | BCP33848 |
中文名 | BO-264 | ||
英文名 | BO-264 | ||
中文别名 | |||
英文别名 | BO 264; BO264; | ||
SMILES | COC1=CC=C(C=C1)C2=NOC(=C2)NC3=NC(=NC=C3)N4CCOCC4 | ||
化学名称 | |||
分子式 | C18H19N5O3 | 分子量 | 353.38 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 demonstrated superior anti-proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against normal breast cells was negligible. |
相关产品推荐
查看更多 >Tags:BO-264 供应商,BO-264 购买,BO-264 生产,BO-264 批量,BO-264 供应,BO-264 订购,BO-264 采购