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BO-264 结构式

BO-264

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货号 :BCP33848CAS号 :2408648-20-2纯度:98%
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  • 基本信息与产品描述
CAS号 2408648-20-2 货号 BCP33848
中文名 BO-264
英文名 BO-264
中文别名
英文别名 BO 264; BO264;
SMILES COC1=CC=C(C=C1)C2=NOC(=C2)NC3=NC(=NC=C3)N4CCOCC4
化学名称
分子式 C18H19N5O3 分子量 353.38
纯度 98% 配送 惯例下常温包邮
产品描述 BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 demonstrated superior anti-proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against normal breast cells was negligible.
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