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ROR

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ROR

结构式 货号 产品名称 CAS号
Cedirogant 结构式
 BCP45156 Cedirogant 2055496-11-0
Cedirogant is a retinoid-related orphan receptor-γt (RORγt) antagonist.
AZD-0284 结构式
 BCP43815 AZD-0284 2101291-07-8
AZD-0284 is a potent, selective, inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis.
SR 2211 结构式
 BCP40332 SR 2211 1359164-11-6
SR-2211 is a synthetic RORγ-selective modulator that potently inhibits production of IL-17 in cells.
TMP778 结构式
 BCP37895 TMP778 1422171-08-1
TMP778 is a selective RORγt inverse agonist.
GSK805 结构式
 BCP31149 GSK805 1426802-50-7
GSK805 is a potent, orally bioavailable RORγγ Inhibitor with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.
Vimirogant 结构式
 BCP30659 Vimirogant 1802706-04-2
Vimirogant is a RORγ inhibitor extracted from patent US 9481674 B1, has a Ki of <100 nM.
SR-0987 结构式
 BCP29012 SR-0987 303126-97-8
SR-0987 is a T cell-specific RORγ (RORγt) agonist.
GSK2981278 结构式
 BCP17156 GSK2981278 1474110-21-8
GSK 2981278 (GSK2981278) is a potent, highly selective RORγ/RORγt inhibitor that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM.
SR 1001 结构式
 BCP09202 SR 1001 1335106-03-0
Retinoic acid receptor-related orphan receptors (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Demonstrates no activity at RORβ or LXR. Suppresses TH17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.
SR3335 结构式
 BCP13177 SR3335 293753-05-6
SR3335 is a selective RORα synthetic ligand, directly binds to RORα (Ki 220 nM) but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays.
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