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MAGL

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MAGL

结构式 货号 产品名称 CAS号
CAY10499 结构式
 BCP46929 CAY10499 359714-55-9
CAY10499 is a potent and selective monoglyceride lipase inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme.
JJKK048 结构式
 BCP46517 JJKK048 1515855-97-6
JJKK 048 is an ultrapotent and highly selective inhibitor of Monoacylglycerol lipase (MAGL).
AA38-3 结构式
 BCP46457 AA38-3 65815-76-1
AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH).
KC01 结构式
 BCP43599 KC01 1646795-59-6
KC01 is a covalent inhibitor of ABHD16A.
JZP-430 结构式
 BCP39983 JZP-430 1672691-74-5
JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
DO-264 结构式
 BCP31625 DO-264 2301866-59-9
DO264 is a novel ABHD12 inhibitor.
URB602 结构式
 BCP19101 URB602 565460-15-3
URB602 is a selective monoacylglycerol lipase (MAGL) inhibitor, which inhibits rat brain MGL with IC50 of 28±4 μM through a noncompetitive mechanism.
ABX-1431 结构式
 BCP29967 ABX-1431 1446817-84-0
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).
KML29 结构式
 BCP16466 KML29 1380424-42-9
KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.
JZL195 结构式
 BCP23894 JZL195 1210004-12-8
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
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