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天然产物
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基础原料
LRRK2
结构式 | 货号 | 产品名称 | CAS号 |
---|
BCP47285 | CZC 54252 hydrochloride 新 | 1784253-05-9 | |
CZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).
|
BCP35880 | MLi-2 新 | 1627091-47-7 | |
MLi-2 is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinson’s disease.
|
BCP34885 | PFE-360 新 | 1527475-61-1 | |
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase.
|
BCP30270 | PF-06454589 新 | 1527473-30-8 | |
PF-06454589 is a potent and selective LRRK2 inhibitor.
|
BCP09654 | GNE-0877 | 1374828-69-9 | |
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.
|
BCP15148 | CZC-54252 | 1191911-27-9 | |
CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively.
|
BCP09557 | CZC-25146.HCl | 1330003-04-7 | |
CZC-25146 Hcl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
|
BCP14116 | CZC 25146 | 1191911-26-8 | |
CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
|
BCP09106 | HG-10-102-01 | 1351758-81-0 | |
HG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC50 for LRRK2-wild-type ~20.3 nM and LRRK2-[G2019S] ~3.2 nM).
|
BCP10209 | GNE9605 | 1536200-31-3 | |
GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.
|