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GPR

结构式 货号 产品名称 CAS号
GPR81 agonist 1 结构式
 BCP36389 GPR81 agonist 1 1620992-67-7
GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively.
TC-G 1001 结构式
 BCP49127 TC-G 1001 494191-73-0
TC-G 1001 is a potent agonist of GPR35, with EC50s of 26 and 3.2 nM in the β-arrestin and Ca2+ release assay, respectively.
NCRW0005F05 结构式
 BCP48739 NCRW0005F05 342779-66-2
NCRW0005-F05 is the first GPR139 antagonist (IC50 = 0.21 µM).
ML 145 结构式
 BCP45167 ML 145 1164500-72-4
ML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.
SCO-267 结构式
 BCP41795 SCO-267 1656261-09-4
SCO-267 is a novel GPR40 full agonist, improving liver parameters in a mouse model of nonalcoholic fatty liver disease without affecting glucose or body weight.
AS1269574 结构式
 BCP43461 AS1269574 330981-72-1
AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays.
TAK041 结构式
 BCP43188 TAK041 1929519-13-0
TAK-041 is a novel Potent and Selective GPR139 Agonist for the Treatment of Negative Symptoms Associated with Schizophrenia.
PSB-SB-487 结构式
 BCP37990 PSB-SB-487 1399049-81-0
PSB-SB-487 is a potent, allosteric GPR55 antagonist
ML-191 结构式
 BCP37828 ML-191 931695-79-3
ML-191 is a potent, selective GPR55 antagonist with 160 nM potency for GPR55 and >100-fold selectivity against GPR35, CB1 and CB2.
AMG-009 结构式
 BCP37558 AMG-009 1027847-67-1
AMG 009 is an orally active, small molecule CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) and DP (D prostanoid) dual antagonist, which was in preclinical development in the US for the treatment of asthma and allergic rhinitis.
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