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BMP/TGF beta Receptor

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BMP/TGF beta Receptor

结构式 货号 产品名称 CAS号
PD 161570 结构式
 BCP24138 PD 161570 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
BMP signaling agonist sb4 结构式
 BCP37563 BMP signaling agonist sb4 100874-08-6
BMP signaling agonist sb4 is a potent and selective BMP4 signaling agonist with EC50 value of 74 nM. It enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.
LDN-212854 结构式
 BCP14671 LDN-212854 143259726-6
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2.
SRI-011381 hydrochloride 结构式
 BCP30374 SRI-011381 hydrochloride SRI011381HCl
SRI-011381 hydrochloride is a TGF-beta signaling agonist.
SRI-011381 结构式
 BCP30372 SRI-011381 1629138-41-5
SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
BIO-013077-01 结构式
 BCP30129 BIO-013077-01 746667-48-1
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
SJ000291942 结构式
 BCP29880 SJ000291942 425613-09-8
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
LDN-193189 2HCl 结构式
 BCP20431 LDN-193189 2HCl 1435934-00-1
LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively.
A 77-01 结构式
 BCP13726 A 77-01 607737-87-1
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
LDN-214117 结构式
 BCP12392 LDN-214117 1627503-67-6
LDN-214117 is a selective inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with high selectivity for BMP versus TGF-β signaling, and low cytotoxicity.
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