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ALK

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ALK

结构式 货号 产品名称 CAS号
BCX-9250 结构式
 BCP49293 BCX-9250 BCX-9250
BCX 9250, is an orally administered, small molecule, inhibitor of activin receptor-like kinase-2 (ALK2).
R-268712 结构式
 BCP25191 R-268712 879487-87-3
R-268712 is a specific inhibitor of activin receptor-like kinase 5 (ALK5). It is also an orally active transforming growth factor-β type I receptor inhibitor.
ZX-29 结构式
 BCP45485 ZX-29 2254805-62-2
ZX-29 is a potent and selective ALK inhibitor for ALK, ALK L1196M and ALK G1202R mutations, respectively.
TPX-0131 结构式
 BCP42131 TPX-0131 2648641-36-3
TPX-0131 is a CNS-penetrant, next-generation ALK inhibitor that has potency against wild-type ALK and a spectrum of acquired resistance mutations, especially the G1202R solvent front mutation and compound mutations, for which there are currently no effective therapies.
TL13-12 结构式
 BCP36914 TL13-12 2229037-04-9
TL13-12 is a novel selective anaplastic lymphoma kinase (ALK) degrader.
TL13-112 结构式
 BCP36884 TL13-112 2229037-19-6
TL13-112 shows chemically induced degradation of anaplastic lymphoma kinase (ALK).
MS4078 结构式
 BCP32539 MS4078 2229036-62-6
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) with a Kd of 19 nM for binding affinity to ALK.
SAR348830 结构式
 BCP31069 SAR348830 1462949-64-9
SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).
BIBF0775 结构式
 BCP30371 BIBF0775 334951-90-5
BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.
SM16 结构式
 BCP30149 SM16 614749-78-9
SM16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
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