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| CAS号 | LXH254HCl | 货号 | BCP30244 |
| 中文名 | LXH254 HCl | ||
| 英文名 | LXH254 HCl | ||
| 中文别名 | |||
| 英文别名 | LXH-254 HCl ;LXH 254 HCl ; LXH254 hydrochloride; LXH-254 hydrochloride; LXH 254 hydrochloride; | ||
| SMILES | O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC(OCCO)=NC(N4CCOCC4)=C3)=C2.[H]Cl | ||
| 化学名称 | |||
| 分子式 | C25H26ClF3N4O4 | 分子量 | 538.95 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LXH254 is an orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, pan-RAF inhibitor LXH254 binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. | ||
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