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CAS号 | 1269440-29-0 | 货号 | BCP44104 |
中文名 | Encorafenib | ||
英文名 | Encorafenib | ||
中文别名 | |||
英文别名 | LGX818; LGX-818; LGX 818; | ||
SMILES | CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC | ||
化学名称 | |||
分子式 | C22H27ClFN7O4S | 分子量 | 540.01 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. |
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