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CAS号 | 896466-04-9 | 货号 | BCP11714 |
中文名 | AT9283 | ||
英文名 | AT9283 | ||
中文别名 | |||
英文别名 | AT 9283; AT-9283; AT-9283 free base; | ||
SMILES | O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5 | ||
化学名称 | |||
分子式 | C19H23N7O2 | 分子量 | 381.44 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML. |
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