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AT9283 结构式

AT9283

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP11714CAS号 :896466-04-9纯度:98%
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  • 基本信息与产品描述
CAS号 896466-04-9 货号 BCP11714
中文名 AT9283
英文名 AT9283
中文别名
英文别名 AT 9283; AT-9283; AT-9283 free base;
SMILES O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5
化学名称
分子式 C19H23N7O2 分子量 381.44
纯度 98% 配送 惯例下常温包邮
产品描述 AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.
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