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CAS号 | SJ10542 | 货号 | BCP46974 |
中文名 | SJ10542 | ||
英文名 | SJ10542 | ||
中文别名 | |||
英文别名 | SJ 10542; SJ-10542; | ||
SMILES | CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC(=N3)NC5=CC=C(C=C5)C(=O)NCCCN6CCN(CC6)C7=CC=C(C=C7)C8CCC(=O)NC8=O | ||
化学名称 | |||
分子式 | C41H46N12O5S | 分子量 | 818.96 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter. |
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