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CAS号 | 1797432-62-2 | 货号 | BCP45577 |
中文名 | Tyk2-IN-5 | ||
英文名 | Tyk2-IN-5 | ||
中文别名 | |||
英文别名 | Tyk2 inhibitor 5; | ||
SMILES | CNC1=CC(=NN2C1=NC=C2C(=O)NC3CC3F)NC4=CC=CN(C4=O)C5=CC=CC=N5 | ||
化学名称 | |||
分子式 | C21H19FN8O2 | 分子量 | 434.43 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Tyk2-IN-5 is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. |
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