AT9283

  • 化学数据
CAS号 896466-04-9 货号 BCP11714
中文名 AT9283
英文名 AT9283
中文别名
英文别名 AT 9283; AT-9283; AT-9283 free base;
分子式 C19H23N7O2 分子量 381.44
  • 用途
生物活性 AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.
信号通路 Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage Jak/Stat Pathway Wnt/Stem Cell Epigenetics 
靶 点 Src/Bcr Abl Aurora JAK 

结构式

本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
全国免费电话:400-099-8200
在线客服:
技术支持:
orders@biochempartner.com
瀚香官网:
www.biochempartner.com
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!