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K-11777 结构式

K-11777

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货号 :BCP48070CAS号 :233277-99-1纯度:98%
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  • 基本信息与产品描述
CAS号 233277-99-1 货号 BCP48070
中文名 K-11777
英文名 K-11777
中文别名
英文别名 APC-3316; APC3316; APC 3316; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316;
SMILES CN1CCN(CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCC3=CC=CC=C3)C=CS(=O)(=O)C4=CC=CC=C4
化学名称
分子式 C32H38N4O4S 分子量 574.73
纯度 98% 配送 惯例下常温包邮
产品描述 K-11777 is a a potent, irreversible cysteine protease inhibitor and a potent and selective CCR4 antagonist. Its therapeutic targets are cruzain, a cysteine protease of the protozoan parasite Trypanosoma cruzi, and cathepsins B and L, which are associated with cancer progression. K777 inhibited both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells (IC50: 57 and 8.9 nmol/l, respectively). K777 induced CCR4 internalization, with a ∼50% reduction of cell surface CCR4. K777 did not inhibit CXCR4-induced chemotaxis or internalization and did not bring about Ca(2+) mobilization by itself.
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