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CAS号 | 1931946-73-4 | 货号 | BCP36481 |
中文名 | Opelconazole | ||
英文名 | Opelconazole | ||
中文别名 | |||
英文别名 | PC 945;PC-945;PC945; | ||
SMILES | O=C(NC1=CC=C(F)C=C1)C(C=C2)=CC=C2N3CCN(C4=CC=C(OC[C@@H]5CO[C@](C6=CC=C(F)C=C6F)(CN7N=CN=C7)C5)C(C)=C4)CC3 | ||
化学名称 | |||
分子式 | C38H37F3N6O3 | 分子量 | 682.73 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively; shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo. |
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