K-11777
CAS号 | 233277-99-1 | 货号 | BCP48070 |
中文名 | K-11777 | ||
英文名 | K-11777 | ||
中文别名 | |||
英文别名 | APC-3316; APC3316; APC 3316; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316; | ||
分子式 | C32H38N4O4S | 分子量 | 574.73 |
生物活性 | K-11777 is a a potent, irreversible cysteine protease inhibitor and a potent and selective CCR4 antagonist. Its therapeutic targets are cruzain, a cysteine protease of the protozoan parasite Trypanosoma cruzi, and cathepsins B and L, which are associated with cancer progression. K777 inhibited both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells (IC50: 57 and 8.9 nmol/l, respectively). K777 induced CCR4 internalization, with a ∼50% reduction of cell surface CCR4. K777 did not inhibit CXCR4-induced chemotaxis or internalization and did not bring about Ca(2+) mobilization by itself. | ||
信号通路 | Protease/Metabolic Enzyme GPCR/G Protein | ||
靶 点 | Cytochrome P450 Cathepsin CCR |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!