ASN007
| CAS号 | 2055597-12-9 | 货号 | BCP48479 |
| 中文名 | ASN007 | ||
| 英文名 | ASN007 | ||
| 中文别名 | |||
| 英文别名 | ASN-007; ASN 007;Erk-IN-3; | ||
| 分子式 | C22H25ClFN7O2 | 分子量 | 473.93 |
| 生物活性 | ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines. | ||
| 上下游产品 | 2055597-39-0（ASN007 benzenesulfonate） | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MEK/ERK | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！