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NI-42

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货号 :BCP43848CAS号 :1884640-99-6纯度:98%
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  • 基本信息与产品描述
CAS号 1884640-99-6 货号 BCP43848
中文名 NI-42
英文名 NI-42
中文别名
英文别名 NI 42; NI42;
SMILES CC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)C#N)N(C1=O)C
化学名称
分子式 C18H15N3O3S 分子量 353.39
纯度 98% 配送 惯例下常温包邮
产品描述 NI-42 is a potent and selective BRPF1 in inhibitor with BRPF1 IC50 = 7.9 nM; LE: 0.45; LLE: 5.6. NI-42 is suitable for cellular and in vivo studies to explore the fundamental biology of these proteins. The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Evaluation of the BRPF family as a potential drug target is at an early stage although there is an emerging understanding of a role in acute myeloid leukemia (AML).
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