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CAS号 | 2080306-23-4 | 货号 | BCP41584 |
中文名 | BAY-299 | ||
英文名 | BAY-299 | ||
中文别名 | |||
英文别名 | BAY 299; BAY299; | ||
SMILES | CC1=CC2=C(C=C1N3C(=O)C4=C5C(=C(C=C4)CCCO)C=CC=C5C3=O)N(C(=O)N2C)C | ||
化学名称 | |||
分子式 | C25H23N3O4 | 分子量 | 429.47 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). |
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