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Ilorasertib hydrochloride 结构式

Ilorasertib hydrochloride

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货号 :BCP45536CAS号 :1847485-91-9纯度:98%
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  • 基本信息与产品描述
CAS号 1847485-91-9 货号 BCP45536
关联产品 1227939-82-3(Ilorasertib)
中文名 Ilorasertib hydrochloride
英文名 Ilorasertib hydrochloride
中文别名
英文别名 ABT348; ABT-348; ABT 348; Abbott 968660; Abbott-968660;ABT-348 hydrochloride;
SMILES C1=CC(=CC(=C1)F)NC(=O)NC2=CC=C(C=C2)C3=CSC4=C3C(=NC=C4C5=CN(N=C5)CCO)N.Cl
化学名称
分子式 C25H22ClFN6O2S 分子量 525.0
纯度 98% 配送 惯例下常温包邮
产品描述 Ilorasertib, also know as ABT-348, is a novel, potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials. ABT-348 has nanomolar potency (IC50) for inhibiting binding and cellular auto-phosphorylation of Aurora B (7 and 13 nM), C (1 and 13 nM) and A (120 and 189 nM). Based upon its unique spectrum of activity, ABT 348 was evaluated and found effective in representative solid tumor (HT1080 and MiaPaCa, tumor stasis) and hematological malignancy (RS4;11, regression) xenografts. These results provide the rationale for clinical assessment of ABT-348 as a therapeutic agent in the treatment of cancer.
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