即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 2230490-29-4 | 货号 | BCP49223 |
中文名 | Tinengotinib | ||
英文名 | Tinengotinib | ||
中文别名 | |||
英文别名 | Tinengotinibum;TT-00420; | ||
SMILES | CC1=C2C(=NN1)NC3=CC(=NC=C3C(=N2)C4=CC=CC=C4Cl)N5CCOCC5 | ||
化学名称 | |||
分子式 | C20H19ClN6O | 分子量 | 394.86 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Tinengotinib is an orally available small molecule inhibitor of Aurora kinases (AKs) A and B, Janus kinases (JAKs), fibroblast growth factor receptors (FGFRs) and vascular endothelial growth factor receptors (VEGFRs), with potential antineoplastic and immunomodulatory activities. Upon oral administration, tinengotinib selectively binds to and inhibits AKs A and B, which inhibit cell division in tumor cells that overexpress AKs. Tinengotinib also targets JAKs that are involved in cytokine signaling and inflammation, and FGFRs and VEGFRs, which are overexpressed in the microenvironment (TME) and contribute to neovascularization, tumor growth and metastasis. These kinases are overexpressed by a wide variety of cancer cell types and drive tumor cell proliferation. |
相关产品推荐
查看更多 >Tags:Tinengotinib 供应商,Tinengotinib 购买,Tinengotinib 生产,Tinengotinib 批量,Tinengotinib 供应,Tinengotinib 订购,Tinengotinib 采购