Ilorasertib hydrochloride
| CAS号 | 1847485-91-9 | 货号 | BCP45536 |
| 中文名 | Ilorasertib hydrochloride | ||
| 英文名 | Ilorasertib hydrochloride | ||
| 中文别名 | |||
| 英文别名 | ABT348; ABT-348; ABT 348; Abbott 968660; Abbott-968660;ABT-348 hydrochloride; | ||
| 分子式 | C25H22ClFN6O2S | 分子量 | 525.0 |
| 生物活性 | Ilorasertib, also know as ABT-348, is a novel, potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials. ABT-348 has nanomolar potency (IC50) for inhibiting binding and cellular auto-phosphorylation of Aurora B (7 and 13 nM), C (1 and 13 nM) and A (120 and 189 nM). Based upon its unique spectrum of activity, ABT 348 was evaluated and found effective in representative solid tumor (HT1080 and MiaPaCa, tumor stasis) and hematological malignancy (RS4;11, regression) xenografts. These results provide the rationale for clinical assessment of ABT-348 as a therapeutic agent in the treatment of cancer. | ||
| 上下游产品 | 1227939-82-3（Ilorasertib） | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Aurora | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！