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CAS号 | 1493694-70-4 | 货号 | BCP09929 |
中文名 | UNC2250 | ||
英文名 | UNC2250 | ||
中文别名 | |||
英文别名 | UNC-2250;UNC 2250; | ||
SMILES | O[C@H]1CC[C@H](NC2=NC(NCCCC)=NC=C2C3=NC=C(CN4CCOCC4)C=C3)CC1 | ||
化学名称 | |||
分子式 | C24H36N6O2 | 分子量 | 440.58 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional antitumor activity. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer. |
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