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UNC2250 结构式

UNC2250

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货号 :BCP09929CAS号 :1493694-70-4纯度:98%
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  • 基本信息与产品描述
CAS号 1493694-70-4 货号 BCP09929
中文名 UNC2250
英文名 UNC2250
中文别名
英文别名 UNC-2250;UNC 2250;
SMILES O[C@H]1CC[C@H](NC2=NC(NCCCC)=NC=C2C3=NC=C(CN4CCOCC4)C=C3)CC1
化学名称
分子式 C24H36N6O2 分子量 440.58
纯度 98% 配送 惯例下常温包邮
产品描述 UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional antitumor activity. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer.
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