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CAS号 | 1646839-59-9 | 货号 | BCP33232 |
中文名 | ONO7475 | ||
英文名 | ONO7475 | ||
中文别名 | |||
英文别名 | ONO-7475; ONO 7475; | ||
SMILES | O=C(C1=CC2=C(N(C3=CC=CC=C3)C1=O)CCCC2=O)NC4=NC=C(OC5=CC=NC6=CC(OC)=C(OC)C=C56)C=C4 | ||
化学名称 | |||
分子式 | C32H26N4O6 | 分子量 | 562.58 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ONO-7475 is a potent, selective, and orally active novel Anexelekto/MER tyrosine kinase inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). |
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