UNC2250

  • 化学数据
CAS号 1493694-70-4 货号 BCP09929
中文名 UNC2250
英文名 UNC2250
中文别名
英文别名 UNC-2250;UNC 2250;
分子式 C24H36N6O2 分子量 440.58
  • 用途
生物活性 UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional antitumor activity. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 TAM Receptor 

结构式

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