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RGFP966 结构式

RGFP966

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP42941CAS号 :1396841-57-8纯度:98%
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  • 基本信息与产品描述
CAS号 1396841-57-8 货号 BCP42941
中文名 RGFP966
英文名 RGFP966
中文别名
英文别名 RGFP-966;RGFP 966;
SMILES C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N
化学名称
分子式 C21H19FN4O 分子量 362.4
纯度 98% 配送 惯例下常温包邮
产品描述 RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Systemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine-conditioned place preference, while simultaneously enhancing long-term object-location memory within subjects. HDAC3 inhibition using a first in class selective inhibitor, RGFP966, resulted in decreased cell growth in CTCL cell lines due to increased apoptosis that was associated with DNA damage and impaired S phase progression. Selective inhibition of HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tumor cells, ultimately leading to cell death.
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