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CAS号 | 1396841-57-8 | 货号 | BCP42941 |
中文名 | RGFP966 | ||
英文名 | RGFP966 | ||
中文别名 | |||
英文别名 | RGFP-966;RGFP 966; | ||
SMILES | C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N | ||
化学名称 | |||
分子式 | C21H19FN4O | 分子量 | 362.4 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Systemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine-conditioned place preference, while simultaneously enhancing long-term object-location memory within subjects. HDAC3 inhibition using a first in class selective inhibitor, RGFP966, resulted in decreased cell growth in CTCL cell lines due to increased apoptosis that was associated with DNA damage and impaired S phase progression. Selective inhibition of HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tumor cells, ultimately leading to cell death. |
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