首页   >  
Cell Cycle/DNA Damage
  • Epigenetics
  >  
HDAC
  >   Resminostat hydrochloride
Resminostat hydrochloride 结构式

Resminostat hydrochloride

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP39644CAS号 :1187075-34-8纯度:98%
全国免运费!免费咨询:400-099-8200 或 手机联系:13472751340
即时询价 ×

* 必填项

请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

  • 基本信息与产品描述
CAS号 1187075-34-8 货号 BCP39644
中文名 Resminostat hydrochloride
英文名 Resminostat hydrochloride
中文别名
英文别名 Resminostat HCl;
SMILES CN(C)CC1=CC=C(C=C1)S(=O)(=O)N2C=CC(=C2)C=CC(=O)NO.Cl
化学名称
分子式 C16H20ClN3O4S 分子量 385.86
纯度 98% 配送 惯例下常温包邮
产品描述 Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6. As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266. This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53. In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study.
  • 技术资料和支持
在购买和使用瀚香生物产品的过程中,您遇到的任何问题,都可以咨询我们的免费热线:400-099-8200,或者和我们的客服 。 我们竭诚解决您的一切疑惑,保证您的舒心顺畅。

相关产品推荐

查看更多 >

Tags:Resminostat hydrochloride 供应商,Resminostat hydrochloride 购买,Resminostat hydrochloride 生产,Resminostat hydrochloride 批量,Resminostat hydrochloride 供应,Resminostat hydrochloride 订购,Resminostat hydrochloride 采购

2853530910