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CAS号 | 1083078-98-1 | 货号 | BCP44306 |
中文名 | Quisinostat HCl | ||
英文名 | Quisinostat HCl | ||
中文别名 | |||
英文别名 | Quisinostat hydrochloride;JNJ26481585; JNJ-26481585; JNJ 26481585; | ||
SMILES | CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl | ||
化学名称 | |||
分子式 | C21H27ClN6O2 | 分子量 | 430.94 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation. |
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