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Quisinostat HCl 结构式

Quisinostat HCl

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货号 :BCP44306CAS号 :1083078-98-1纯度:98%
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  • 基本信息与产品描述
CAS号 1083078-98-1 货号 BCP44306
中文名 Quisinostat HCl
英文名 Quisinostat HCl
中文别名
英文别名 Quisinostat hydrochloride;JNJ26481585; JNJ-26481585; JNJ 26481585;
SMILES CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl
化学名称
分子式 C21H27ClN6O2 分子量 430.94
纯度 98% 配送 惯例下常温包邮
产品描述 Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.
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