RGFP966
| CAS号 | 1396841-57-8 | 货号 | BCP42941 |
| 中文名 | RGFP966 | ||
| 英文名 | RGFP966 | ||
| 中文别名 | |||
| 英文别名 | RGFP-966;RGFP 966; | ||
| 分子式 | C21H19FN4O | 分子量 | 362.4 |
| 生物活性 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Systemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine-conditioned place preference, while simultaneously enhancing long-term object-location memory within subjects. HDAC3 inhibition using a first in class selective inhibitor, RGFP966, resulted in decreased cell growth in CTCL cell lines due to increased apoptosis that was associated with DNA damage and impaired S phase progression. Selective inhibition of HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tumor cells, ultimately leading to cell death. | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | HDAC | ||
结构式
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