艾乐替尼盐酸盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09075CAS号：1256589-74-8纯度：98%

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CAS号	1256589-74-8	货号	BCP09075
关联产品	1256580-46-7（艾乐替尼）
中文名	艾乐替尼盐酸盐
英文名	Alectinib Hydrochloride
中文别名	盐酸艾乐替尼;
英文别名	CH-5428402 HCl; AF-802 Hydrochloride; RG-7853 Hydrochloride; RO-5424802 Hydrochloride;
SMILES	[H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1
化学名称
分子式	C30H35ClN4O2	分子量	519.08
纯度	98%	配送	惯例下常温包邮
产品描述	Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with IC50 of 1.9 nM, the dissociation constant (KD) value for ALK in an ATP-competitive manner is 2.4 nM using a competition-bind assay.Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. Alectinib inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.

艾乐替尼盐酸盐 新