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| CAS号 | 1357920-84-3 | 货号 | BCP29521 |
| 中文名 | Belizatinib | ||
| 英文名 | Belizatinib | ||
| 中文别名 | |||
| 英文别名 | TSR011; TSR011; TSR 011; | ||
| SMILES | O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5 | ||
| 化学名称 | |||
| 分子式 | C33H44FN5O3 | 分子量 | 577.73 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Belizatinib, also known as TSR-011, is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity. Upon administration, ALK/TRK inhibitor TSR-011 binds to and inhibits both ALK and TRK kinases. The inhibition leads to disruption of ALK- and TRK-mediated signaling and impedes tumor cell growth in ALK/TRK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. | ||
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