艾乐替尼盐酸盐
| CAS号 | 1256589-74-8 | 货号 | BCP09075 |
| 中文名 | 艾乐替尼盐酸盐 | ||
| 英文名 | Alectinib Hydrochloride | ||
| 中文别名 | 盐酸艾乐替尼; | ||
| 英文别名 | CH-5428402 HCl; AF-802 Hydrochloride; RG-7853 Hydrochloride; RO-5424802 Hydrochloride; | ||
| 分子式 | C30H35ClN4O2 | 分子量 | 519.08 |
| 生物活性 | Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with IC50 of 1.9 nM, the dissociation constant (KD) value for ALK in an ATP-competitive manner is 2.4 nM using a competition-bind assay.Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. Alectinib inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. | ||
| 上下游产品 | 1256580-46-7（艾乐替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | ALK | ||
结构式
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