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CAS号 | 1032350-13-2 | 货号 | BCP01821 |
关联产品 | 1032349-93-1(MK-2206) | ||
中文名 | MK-2206 2HCl | ||
英文名 | MK-2206 2HCl | ||
中文别名 | |||
英文别名 | MK2206;MK 2206; | ||
SMILES | |||
化学名称 | |||
分子式 | C25H23Cl2N5O | 分子量 | 480.39 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. |
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