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MK-2206 2HCl 结构式

MK-2206 2HCl

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货号 :BCP01821CAS号 :1032350-13-2纯度:98%
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  • 瀚香生物(Biochempartner)的MK-2206 2HCl被文献引用
  • 基本信息与产品描述
CAS号 1032350-13-2 货号 BCP01821
关联产品 1032349-93-1(MK-2206)
中文名 MK-2206 2HCl
英文名 MK-2206 2HCl
中文别名
英文别名 MK2206;MK 2206;
SMILES
化学名称
分子式 C25H23Cl2N5O 分子量 480.39
纯度 98% 配送 惯例下常温包邮
产品描述 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death.
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