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MK-2206 结构式

MK-2206

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货号 :BCP20200CAS号 :1032349-93-1纯度:98%
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  • 瀚香生物(Biochempartner)的MK-2206被文献引用
  • 基本信息与产品描述
CAS号 1032349-93-1 货号 BCP20200
关联产品 1032350-13-2(MK-2206 2HCl)
中文名 MK-2206
英文名 MK-2206
中文别名
英文别名 MK 2206;MK2206;
SMILES C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N
化学名称
分子式 C25H21N5O 分子量 407.48
纯度 98% 配送 惯例下常温包邮
产品描述 MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. It also inhibits tumor growth in animal models of nasopharyngeal cancer.
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