MK-2206 2HCl

  • 化学数据
CAS号 1032350-13-2 货号 BCP01821
中文名 MK-2206 2HCl
英文名 MK-2206 2HCl
中文别名
英文别名 MK2206;MK 2206;
分子式 C25H23Cl2N5O 分子量 480.39
  • 用途
生物活性 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death.
上下游产品 1032349-93-1(MK-2206)
信号通路 PI3K/Akt/mTOR 
靶 点 AKT 

结构式

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