MK-2206

  • 化学数据
CAS号 1032349-93-1 货号 BCP20200
中文名 MK-2206
英文名 MK-2206
中文别名
英文别名 MK 2206;MK2206;
分子式 C25H21N5O 分子量 407.48
  • 用途
生物活性 MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. It also inhibits tumor growth in animal models of nasopharyngeal cancer.
上下游产品 1032350-13-2(MK-2206 2HCl)
信号通路 PI3K/Akt/mTOR 
靶 点 AKT 
  • 引用文献
Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma

购于瀚香生物(Biochempartner)的MK-2206(CAS:1032349-93-1)被引用

结构式

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