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基础原料

NFκB

结构式 货号 产品名称 CAS号
CAY10576 结构式
 BCP24906 CAY10576 862812-98-4
CAY10576 is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.
Edasalonexent 结构式
 BCP25138 Edasalonexent 1204317-86-1
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
Vamorolone 结构式
 BCP47443 Vamorolone 13209-41-1
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
Sodium salicylate 结构式
 BCP47031 水杨酸钠 54-21-7
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
IMD-0560 结构式
 BCP46800 IMD-0560 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Sappanone A 结构式
 BCP46467 苏木酮A 102067-84-5
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.
SM-7368 结构式
 BCP46452 SM-7368 380623-76-7
SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
NDMC101 结构式
 BCP46451 NDMC101 1308631-40-4
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
WAY-204688 结构式
 BCP46376 WAY-204688 796854-35-8
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT-1 cells).
Nrf2 activator-1 结构式
 BCP45478 Nrf2 activator-1 2230697-41-1
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2).
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