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CAS号 | 862505-01-9 | 货号 | BCP27665 |
中文名 | LY2322600 | ||
英文名 | LY2322600 | ||
中文别名 | |||
英文别名 | LY 2322600;LY-2322600; | ||
SMILES | CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O | ||
化学名称 | |||
分子式 | C25H33FN6O3S | 分子量 | 516.64 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | LY2228820 is a novel and potent p38MAPK inhibitor. In vitro kinase enzyme activity showed that the IC50 for p38αMAPK and p38βMAPK of LY2228820 were 7 nM and 3 nM, respectively. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs. |
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