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CAS号 | 1358027-80-1 | 货号 | BCP49370 |
中文名 | (S)-(-)-PH-797804 | ||
英文名 | (S)-(-)-PH-797804 | ||
中文别名 | |||
英文别名 | PH 797804;PH-797804;PH797804; | ||
SMILES | CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C | ||
化学名称 | |||
分子式 | C22H19BrF2N2O3 | 分子量 | 477.3 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active. |
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